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Corticotropin-like intermediate peptide

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Title: Corticotropin-like intermediate peptide  
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Subject: Melanocyte-stimulating hormone, Cholecystokinin, Melanocortin, Proopiomelanocortin, Dexamethasone suppression test
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Corticotropin-like intermediate peptide

Symbol POMC
Entrez 5443
HUGO 9201
OMIM 176830
RefSeq NM_000939
UniProt P01189
Other data
Locus Chr. 2 p23
Corticotropin-like intermediate peptide
IUPAC name
Molar mass 2465.668 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally-occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),[1][2] which in turn is a cleavage product of proopiomelanocortin (POMC).[3] Although it does not appear to play any particularly important roles in the body,[4] it does have some biological activity,[5][6] especially of the neurological variety.[7][8][9][10][11]


  1. ^ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry 254 (23): 11903–6.  
  2. ^ Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. p. 78.  
  3. ^ Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. p. 12.  
  4. ^ Larry Rex Engelking (1 June 2002). Review of veterinary physiology. Teton NewMedia. p. 411.  
  5. ^ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation 74 (5): 1886–9.  
  6. ^ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin 26 (1): 99–111.  
  7. ^ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. p. 136.  
  8. ^ Chastrette N, Cespuglio R, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides 15 (2): 61–74.  
  9. ^ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides 15 (2): 75–88.  
  10. ^ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine 147 (3): 319–22.  
  11. ^ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides 14 (6): 1221–4.  

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