World Health Organization : Technical Report Series, No. 674: Treponemal Infections

By E. M. C. Dunlop

Book Id: WPLBN0000175889
Format Type: PDF eBook
File Size: 2.8 MB
Reproduction Date: 2005

Title:	World Health Organization : Technical Report Series, No. 674: Treponemal Infections
Author:	E. M. C. Dunlop
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago C. Dunlo, E. M. (n.d.). World Health Organization : Technical Report Series, No. 674. Retrieved from http://www.gutenberg.cc/

Description
Medical Reference Publication

Excerpt
1. INTRODUCTION In 1975, following the Technical Discussions at the Twenty-eighth World Health Assembly on Social aspects of sexually transmitted diseases: need for a better approach, the Health Assembly in resolution WHA 28.58 invited governments to make optimal use of existing services and health structures to strengthen the control of sexually transmitted diseases, including syphilis, and requested the Director- General of WHO to provide Member States uith the ad~icean d assistance necessary for a fuller appreciation of the public health aspects of these diseases. In 1978, the World Health Assembly also requested the Director-General of WHO to draw up, disseminate, and update, as required, guidelines on the control of sexually transmitted diseases (resolution WHA 3 1.57). Syphilis and the nonvenereal treponematoses nere considered in depth by the WHO Expert Committee on Venereal Infections and Treponematoses in 1953 (1 ) and 1959 (2). and again by the WHO Scientific Group on Treponematoses Research in 1970 (3). The objective of this latest meeting was to review all aspects of the treponematoses and to provide updated standards and guidelines for their diagnosis, treatment, and control

Table of Contents
CONTENTS 1 . Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 2 . Epidemiological aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 2.1 Syphilis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 2.2 Nonvenereal treponematoses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .19 3 . Clinical aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20 3.1 Venerealsyphilis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20 3.2 Nonvenereal treponematoses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .23 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24 4 . Laboratory aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25 4.1 Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .25 4.2 Microscope tests used to identify treponemes . . . . . . . . . . . . . . . . . . . . . . . . .25 4.3 Serological tests for the detection of antibodies in individuals with tre- ponemal infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27 4.4 Diagnosis of neurosyphilis by cerebrospinal fluid (CSF) examination References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 . Management aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.1 Treatment of early acquired syphilis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.2 Treatment of late syphilis .......................................... 5.3 Diagnosis and management of syphilis in prepnancy . . . . . . . . . . . . . . . . . . . 5.4 Treatment of congenital syphilis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.5 Recommendations for follow-up of patients treated for syphilis, all stages 5.6 Contact treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.7 Penicillin reactions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5.8 Management of nonvenereal rreponematoses . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . Controlaspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.1 Objectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.2 SyphiEscontrol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6.3 Control of nonvenereal treponematoses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 . Researchaspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7.1 Investigation of 7 . pallidlmt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7.2 Immunity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7.3 New paramete