A Summary of the Symposium on the Environmental Genome Project

By Department of Health and Human Services

Book Id: WPLBN0000201882
Format Type: PDF eBook:
File Size: 3.07 MB
Reproduction Date: 2005

Title:	A Summary of the Symposium on the Environmental Genome Project
Author:	Department of Health and Human Services
Volume:
Language:	English
Subject:	Health., Medical research, Medical reports
Collections:	Medical Library Collection
Historic Publication Date:
Publisher:	Centers for Disease Control and Prevention


Citation APA MLA Chicago Of Health And Human Services, B. D. (n.d.). A Summary of the Symposium on the Environmental Genome Project. Retrieved from http://www.gutenberg.cc/

Excerpt
FOREWORD: In October of 1997, the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), on its Bethesda campus, sponsored a symposium, a two-day series of talks to help shape a comprehensive research initiative: the Environmental Genome Project. This special report will provide attendees a refresher course on the issues raised by our distinguished panel of speakers, among the top experts in their disciplines. We hope it will give other readers who were not present, whether they be scientists, policymakers or the lay public, a sense of the broad, complex terrain covered during the symposium. We hope, too, this report will serve as a primer on the themes that are likely to inform and guide the Environmental Genome Project for years to come...

Table of Contents
CONTENTS ... Contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Foreword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Agenda . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi Session I: Gene-Environment Interactions in Human Diseases . . . . . . . . . . . . . . . . . 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Examples of Polymorphisms in Disease Susceptibility . . . . . . . . . . . . . . . . . 3 Examples of Gene-Environmental Interactions . . . . . . . . . . . . . . . . . . . . . . . . 4 Issues Associated with the Environmental Genome Project . . . . . . . . . . . . . . 7 Session 11: Population Sampling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9 Allelle Identification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 0 Frequency Distributions of Polymorphisms . . . . . . . . . . . . . . . . . . . . . . . . 12 Session 111: Technologies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1 5 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 DNASequencing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Chip Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Session IV: Population-Based Epidemiological Studies . . . . . . . . . . . . . . . . . . . . . 19 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Opportunities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 1 Optimizing Study Designs and Power . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 4 Session V: Functional Analysis of Polymorphisms . . . . . . . . . . . . . . . . . . . . . . . . . 27 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Functional Analysis Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2 9 Gene Expression Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 1 Session VI: Ethical. Legal. Social Issues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 Ethical and Social Issues in Sampling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Informed Consent, Potential Impact on Susceptible Groups . . . . . . . . . . . . . . 38